My father always liked his 700 BDL in 22 250 For harvesting deer on the fruit farm he grew up on. He did not have to shoot more than 150 yds. All head shots.
Yes indeed !!! My favorite for deer out to open 450yds., head shots only ( I would like to say 100% but i shot a fence post instead of the deer at dusk at 300 yds one night. I had what I thought was a beauty of a throat,jaw shot but after it ran away my crosshairs were actually off to one side of the post, the deer was standing in front of. The fence post was pretty useless after that.)
On everything else, in calm wind, down to squirrels (again head shots only and at long range) 6MM hornady .243 Spitze HPBT 58 gr. Loaded to around 3600 FPS out of the Ruger M77V with Leopold vX3 3.5-10, and now the VORTEX Viper PST 4-16x50 EBR scope.
On windy daze, The .270win out of Ruger M77 is a sure pleaser !
For short range < 100 yds the savage A22 with The old Leopold 3.5x10 pushing the CCI A22 ammo, head shots only, has worked well.
I do not consider myself a hunter. Just a harvester.
For urban ground hog warfare I like the Sam Yang RECLUSE .357, 81 gr DIABLO with sound attenuater.